A vaccine against malaria has been shown to be highly effective in trials in Africa, holding out the real possibility of slashing the death toll of a disease that kills 400,000 mostly small children every year.

The vaccine, developed by scientists at the Jenner Institute of Oxford University, showed up to 77% efficacy in a trial of 450 children in Burkina Faso over 12 months.

The hunt for a malaria vaccine has been going on the best part of a century. One, the Mosquirix vaccine developed by GlaxoSmithKline, has been through lengthy clinical trials but is only partially effective, preventing 39% of malaria cases and 29% of severe malaria cases among small children in Africa over four years. It is being piloted by the World Health Organization in parts of Kenya, Ghana and Malawi.

The Oxford vaccine is the first to meet the WHO goal of 75% efficacy against the mosquito-borne parasite disease. Larger trials are now beginning, involving 4,800 children in four countries.

Prof Adrian Hill, director of the Jenner Institute, where the Oxford/AstraZeneca Covid vaccine was invented, said he believed the vaccine had the potential to cut the death toll dramatically. “What we’re hoping to do is take that 400,000 down to tens of thousands in the next five years, which would be absolutely fantastic.”

Other interventions, such as impregnated bednets and malarial drugs, have reduced the death toll from a million a year, he said, and those must continue. But, if the vaccine could cut deaths to the tens of thousands, they might be able to look towards “a greater goal – eventually eradicating malaria”.

Hill said the institute might apply for emergency approval for the malaria vaccine just as it did for the Covid jab. “I’m making the argument as forcefully as I can, that because malaria kills a lot more people than Covid in Africa, you should think about emergency-use authorisation for a malaria vaccine for use in Africa. And that’s never been done before.”

The institute would probably ask the regulatory bodies in Europe or the UK for a scientific opinion on the vaccine and then apply to the World Health Organization for approval for use in Africa. “They did Covid in months – why shouldn’t they do malaria in a similar length of time as the health problem is an even greater scale in Africa?” Hill said.

The vaccine will be manufactured at large scale and low-cost, say the researchers, who have arranged a deal with the Serum Institute of India, which is involved in manufacturing the Oxford/AstraZeneca Covid-19 vaccine.

The Serum Institute has had to delay supplies of the Covid vaccine to the rest of the world because of the huge rise in cases in India, but has promised to deliver 200m doses a year of the malaria vaccine if it is licensed.

Hill said the best-case scenario was approval by the end of 2022, by which time the Serum Institute would have plenty of capacity.

Dr Cyrus Poonawalla and Adar Poonawalla, respectively chair and CEO of the Serum Institute, said in a statement that they were “highly excited to see these results on a safe and highly effective malaria vaccine which will be available to the whole world”. The project was through collaboration with Oxford and also Novavax, which is supplying the adjuvant, a substance that enhances the immune system response.

“We are highly confident that we will be able to deliver more than 200m doses annually in line with the strategy, as soon as regulatory approvals are available,” they said.

Gareth Jenkins, of Malaria No More UK, said: “We can end malaria in our generation but only if governments invest in the research needed to deliver the new medicines and products that can accelerate the end of this terrible disease.

“The Jenner Institute’s groundbreaking work on both the new Covid-19 and malaria vaccines is a great example of this and demonstrates just how much humanity’s safety is dependent on new science.

“An effective and safe malaria vaccine would be a hugely significant extra weapon in the armoury needed to defeat malaria, which still kills over 270,000 children every year. For decades British scientists have been at the forefront of developing new ways to detect, diagnose, test and treat malaria, and we must continue to back them.

“A world without malaria is a world safer both for the children who would otherwise be killed by this disease, and for us here at home. Countries freed from the malaria burden will be much better equipped to fight off new disease threats when they inevitably emerge in the future.”

MORE: https://www.theguardian.com/world/2021/apr/23/oxford-malaria-vaccine-proves-highly-effective-in-burkina-faso-trial

https://www.christianitytoday.com/ct/podcasts/quick-to-listen/malaria-vaccine-africa-mosquito-covid-19-podcast.html

Pray for all those who suffer from Malaria each year.
Pray for the many young children who endure suffering and death at the hands of this disease.
Pray with thanksgiving for the scientists working to eradicate this disease.
Pray for the success of the vaccine and that money and politics will not hinder successful distribution.

Pope Francis’ first-ever papal trip to Iraq marked a watershed moment in relations between the Catholic Church and the Middle East. Yet for all the optimism of the Pope’s message, his visit also serves to remind us that Christianity and other minority faiths of the region are facing dark times.

The Middle East is the cradle of the three Abrahamic faiths that have more than 4 billion adherents around the globe. The region remains home to some of the world’s most ancient languages, cultures and heritage sites.

Yet oppressive governments and violent extremist movements have been busy erasing the Middle East’s diverse religious communities. Today, Syria and Yemen have lost almost all of their Jews, while Turkey has done the same with its Chaldean Christians, ethnic Syriacs who follow the Catholic rite. Iraq’s Yazidis, a Kurdish-speaking community that adheres to a long-persecuted ancient monotheistic faith narrowly escaped destruction during the Islamic State’s genocidal campaign. Iraq’s Mandaeans, followers of another indigenous Middle Eastern faith, also fear extinction.

Governments should take a stand to defend diversity and pluralism in the Middle East and beyond. Security assurances to protect embattled communities from future genocidal campaigns, substantial development aid for rebuilding them and support for inclusive institutions can all play a role.

Mideast religious minorities face a particularly potent threat from the insidious collaboration between authoritarian states and violent extremist groups, as proxy wars have come to replace conventional warfare between nation-states. The growing footprint of non-state actors has exacerbated the danger to religious minorities.

The Islamic State, for example, recruited foreign fighters from all corners of the globe as it targeted the Yazidi community with its genocidal campaign of mass executions, rape and enslavement. As the Economist recently noted, many Yazidis who escaped the immediate threat when the Islamic State was defeated militarily are still fighting for their survival.

Although Syrian dictator Bashar al-Assad presents himself as the protector of minorities, especially Christians, he has executed and tortured critics regardless of their religion. The Assad regime’s indiscriminate massacre of its own citizens with barrel bombs and chemical weapons not only received financial support from Moscow and Tehran, but also utilized Russian private military contractors and Iran’s militias recruited all the way from Lebanon to Afghanistan.

In northern Syria, according to a report of the U.N. Commission of Inquiry on Syria, Turkey’s proxies committed war crimes targeting Kurds and Yazidis, including hostage-taking, torture, rape and pillaging, in addition to violating international humanitarian law by looting and destroying cultural property.

Since Turkey’s failed coup attempt in 2016, the country’s increasingly authoritarian government intensified its scapegoating of Christians, Jews and Alevis (a Muslim minority). The revisionist historical dramas on Turkish state television have become the new means through which antisemitic, anti-Christian and anti-Western conspiracies are distributed in multiple languages around the world. Social media platforms compound the problem by amplifying hateful messages from state-funded media and the propaganda outlets of violent extremist groups.

Since the Iranian revolution, the Islamic republic has not only decimated the country’s Jewish community, taking its numbers from 100,000 to below 9,000, but also threatened to wipe the Jewish state off the “global political map.” Last year Iranian Foreign Minister Mohammad Javad Zarif went so far as to invoke the Nazi phrase “the final solution,” echoing Supreme Leader Ayatollah Ali Khamenei’s vow to uproot and destroy the “cancerous tumor” of Israel. A new Anti-Defamation League study of Iranian textbooks found that the Islamic republic teaches antisemitism and incites schoolchildren against the Jewish people as well as the United States.

No scientific study, media report or opinion poll can give a more accurate account of the state of the Middle East’s minorities than demographic trends. As vulnerable minorities vote with their feet, we continue to witness a mass exodus of ancient communities. A 2019 report commissioned by the British foreign secretary warned that Iraq’s Christian population fell from 1.5 million before 2003 to possibly less than 120,000. Turkey’s Greek Orthodox, Jewish and Syriac Christian citizens are more likely to live in diasporas rather than in their original homes. Coptic Christians still number around 10 million in Egypt, but according to the Hudson Institute’s Samuel Tadros, the Coptic church is blossoming “outside Egypt’s borders.”

U.S. leadership and cooperation with transatlantic allies are imperative to reversing these alarming trends. As the Biden administration emphasizes making human rights central to U.S. foreign policy, the Middle East’s endangered religious minorities should be one of its priorities.

More: https://www.washingtonpost.com/opinions/2021/03/08/middle-easts-religious-minorities-are-facing-extinction-world-must-act/

Pray for persecuted Christians in the Middle East, particularly in Iraq, Turkey and Syria

Pray persecuted believers would know the hope God brings 

Pray for international leadership from leading nations, that they may stand up for the oppressed and disempowered